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Diffusion and osmosis.

Molecules wander at random, yet sugar spreads out and water climbs through membranes. See how random motion moves water into cells or out of them.

Explore the scene Interactive article

01 / The experiment

Water goes where the sugar is.

Pick a membrane, change how much is dissolved on the right or outside, then look inside at the molecules.

Still of the Diffusion and osmosis 3D scene, which explores: Why does drinking seawater leave you thirstier?
Interactive scene

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The explanation below is available while the scene loads.

The left side and the inside of the cell hold 300 mOsm/L of dissolved particles, about the strength of blood. Sugar in the tank, salt round the cell.Molecules and the membrane are drawn millions of times larger than the tank, and far fewer. The orange dye only marks where sugar or salt is; real solutions are clear. Time is sped up, and the tiny back-pressure of the raised water is ignored.

02 / Three solutions

One cell, three baths.

The same red blood cell gains, keeps or loses water depending only on what is dissolved around it.

Hypotonic · weaker outside01

Pure water

With nothing dissolved outside, more water crosses in than out. The cell swells into a sphere until its membrane can stretch no further and tears.

Outside
Weaker than inside
Water moves
Into the cell
The cell
Swells round, then bursts
Isotonic · equal02

Like blood

Saline drips are made at this strength. Water still crosses all the time, but as much leaves as enters, so the cell keeps its shape.

Outside
Matches inside
Water moves
Both ways, equally
The cell
A dimpled disc
Hypertonic · stronger outside03

Seawater

Outside is now the crowded side. More water leaves than enters, and the cell shrinks into a spiky, crenated ball.

Outside
Stronger than inside
Water moves
Out of the cell
The cell
Shrivels and crinkles
The big idea

Molecules wander at random, so they spread from crowded to sparse. Across a membrane that stops dissolved particles, it is the water that moves, towards the side with more dissolved.

π = cRT

A drop that spreads by itself

Drop food colouring into a still glass of water and wait. Nobody stirs, yet the colour creeps outward until the whole glass is evenly tinted, faster in warm water than in cold.

This is diffusion: dissolved particles spreading from where they are crowded to where they are scarce. Nothing pushes them. Every molecule in a liquid is constantly jostled by its neighbours and wanders on a random, zigzag path, heading nowhere in particular.

Random steps, one-way result

If each molecule moves at random, why does the colour only ever spread out? Because of numbers. Where molecules are crowded, many happen to wander outward; where they are scarce, few happen to wander back. The difference is a net flow from high concentration to low, and it stops only when the mix is even. Even then the molecules keep moving; they just cross in both directions equally.

Warmth makes molecules jostle harder and water runnier: sugar diffuses about twice as fast at 50 °C as at 20 °C. Diffusion is quick over tiny distances and painfully slow over large ones: a sugar molecule crosses a cell in about a tenth of a second, but needs about a day to wander a single centimetre. Large animals need hearts to carry things further.

A wall with small doors

Every cell is wrapped in a membrane, a film two molecules thick made of fatty phospholipids, with their water-loving heads facing out and oily tails tucked inside. Water slips through, helped by protein channels, but sugar and the charged ions of salt are mostly kept out. A membrane like this is called selectively permeable.

Osmosis: water follows the dissolved particles

Now put a selectively permeable membrane between pure water and sugar water. Sugar cannot cross, but water can, and it does so in both directions. On the sugary side, some of the space next to the membrane is taken up by sugar, which also holds on to water molecules, so slightly fewer water molecules cross from that side. The net result is that water moves into the sugar solution, and its level rises. This is osmosis: water diffusing across a membrane towards the side with more dissolved particles.

Try it: set Membrane to Only water crosses and the right side to Pure water, and watch the left side fill up. Then choose Sugar can cross: now the sugar spreads instead and the levels stay put. Choose On under Show the molecules to see the net-flow arrows.

Back to the experiment

Cells in the balance

Choose Red blood cell. The fluid around a cell is called isotonic when it holds the same concentration of dissolved particles as the inside, hypotonic when it holds less, and hypertonic when it holds more. In pure water the cell takes in water until it bursts; in saltier water than blood it loses water and shrivels into a spiky ball. That is why drips in hospitals use saline at the same strength as blood.

It also explains why seawater makes you thirstier. Seawater holds more than three times as many dissolved particles as blood. Your kidneys cannot make urine salty enough to get rid of that salt without spending more water than you drank, so your cells end up losing water. Plants use osmosis the other way: water drawn into their cells presses outward against stiff cell walls, keeping stems firm. Without enough water, that pressure drops and the plant wilts.

What this model leaves out

The Scene shows a few hundred molecules where a real drop holds trillions upon trillions. Real osmosis through a cell membrane is driven by pressure as well as by random crossings, and the push can be enormous: blood-strength solution could, in principle, hold up a column of water more than seventy metres tall. The tank ignores that back-pressure entirely. The red blood cell’s volume follows a standard textbook relation, but real cells also pump ions and vary in how far they stretch before bursting.

Reuse with credit to ViewWiki and a link to this page.

04 / Learn this in a course

Practise it, step by step.

These 3 lessons teach the topic with checked questions, in course order.

  1. Diffusion Biology · Transport in cells
  2. Osmosis Biology · Transport in cells
  3. Cells in solutions Biology · Transport in cells