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Lesson 2 of 4

The immune response.

About 20 minutes · 4 practice questions

A first meeting with a virus: how fast it multiplies, what antibodies are, why the virus peaks before they rise, and how many days you feel ill.

Step 1 of 4 · A first meeting

Step 1 of 4

A first meeting

The body fights pathogens on two lines. Innate immunity acts at once and against any invader: the skin, the mucus, stomach acid, and white blood cells that swallow anything that looks foreign. Adaptive immunity learns: it recognises one particular pathogen, and it takes time.

In the Scene a virus lands on the airway lining of someone who has never met it. Vaccine is fixed at None, and Days since infection stands at day two. The upper chart shows the virus on a logarithmic scale: each gridline is a factor of ten.

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Step 2 of 4

Antibodies

Everyone has millions of kinds of B cell, each carrying an antibody of a different shape on its surface. When a virus arrives, only the few whose antibody fits it bind to it. With help from helper T cells they divide again and again, and some become plasma cells that pour out antibodies. Days since infection stands at day fourteen.

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Step 3 of 4

The race

At a first meeting there is a race: the virus multiplies, and the immune system searches for and multiplies the matching cells. Start from the day the virus lands, and think about who will lead in the first week.

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Step 4 of 4

Days ill

You feel ill while the virus is above a certain level, mostly because of the inflammation the immune system itself stirs up: fever, tiredness, aches. The upper chart marks that level with a dashed line. Days since infection stands at Three weeks on.

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Still of the Immune system and vaccines 3D scene
Interactive scene

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Each step sets up the Scene for you, and a control marked “fixed” stays put for that step.

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Practice · Calculate

At a first meeting with the virus, without a vaccine, it grows from 100 copies per millilitre on day 0 to about 17,300 on day 2. By what factor does it grow each day, if the growth multiplies?

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Practice · Choose

After about a week antibodies start to appear. What is an antibody?

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Practice · Predict, then look

At a first meeting, without a vaccine, the virus multiplies and antibodies start to appear. Which will come first?

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Practice · Calculate

Without a vaccine, how many days in all do you feel ill, with the virus above the level that makes you feel unwell? Read it at the foot of the chart, on day 21.